Diagnosis dan Tatalaksana Pneumonitis Hipersensitif

Muhammad Rizki Akbar(1Mail), Putu Ristyaning Ayu Sangging(2),
(1) Universitas Lampung, Indonesia
(2) Universitas Lampung, Indonesia

Mail Corresponding Author

DOI : https://doi.org/10.30604/well.55212020

Full Text:    Language : ind


Hypersensitive pneumonitis (HP), also known as extrinsic allergic alveolitis, is a complex pulmonary syndrome mediated by the immune system and caused by inhalation of various antigens that have previously been sensitized by the individual. The pathobiology of this disease is not fully understood, but in addition to the triggers that initiate the disease, genetic factors tend to be necessary, because only a small proportion of people are exposed to HP. Because of the lack of standard diagnostic standards, the diagnosis of HP is not directly established and depends on several factors, including the history of exposure, antibodies present in specific antigens, clinical features, bronchoalveolar lavage (LAB), and radiological and pathological features. However, in proper management, high suspicion is significant and can negate the need for more invasive tests. Clinical manifestations and allergic history vary greatly. Corticosteroids may be useful in acute episodes to relieve symptoms or chronic progressive disease, but their long-term effects have never been validated in prospective clinical trials. We conduct a systematic review of published journals about HP. The search uses the Pubmed database using the medical term (MeSH) until January 2020. A total of 13 journals and one textbook were identified.


Extrinsic allergic alveolitis; Diagnosis; Pathogenesis; Hypersensitive pneumonitis; Management


  1. Selman M, Pardo A, King TE. Hypersensitivity Pneumonitis. Am J Respir Crit Care Med. 2012;186(4):314–24.
  2. Spagnolo P, Rossi G, Cavazza A, Bonifazi M, Paladini I, Bonella F, et al. Hypersensitivity Pneumonitis : A Comprehensive Review. J Investig Allergol Clin Immunol. 2015;25(4):237–50.
  3. Gifford AH, Enelow RI. Hypersensitivity Pneumonitis. In: Fishman’s Pulmonary Diseases and Disorders. Philadelphia: McGraw-Hill; 2015. p. 875–83.
  4. Quirce S, Vandenplas O, Campo P, Cruz MJ, de Blay F, Koschel D, et al. Occupational hypersensitivity pneumonitis: an EAACI position paper. Allergy. 2016 Jun;71(6):765–79.
  5. Shiroshita A, Tanaka Y, Nakashima K, Furukawa Y, Kataoka Y. Diagnostic accuracy of specific IgG antibodies for bird fancier’s lung: a systematic review and meta-analysis. Ann Transl Med. 2019 Nov;7(22):655.
  6. Miller R, Allen TC, Barrios RJ, Beasley MB, Burke L, Cagle PT, et al. Hypersensitivity Pneumonitis A Perspective From Members of the Pulmonary Pathology Society. Arch Pathol Lab Med. 2018 Jan;142(1):120–6.
  7. Vasakova M, Morell F, Walsh S, Leslie K, Raghu G. Hypersensitivity Pneumonitis : Perspectives in Diagnosis and Management. Am J Respir Crit Care Med. 2017;196(6):680–9.
  8. Churg A, Ryerson CJ. The Many Faces of Hypersensitivity Pneumonitis. Chest. 2017;152(3):458–60.
  9. Barnes H, Morisset J, Molyneaux P, Westall G, Glaspole I, Collard HR. A systematically derived exposure assessment instrument for Chronic Hypersensitivity Pneumonitis. Chest. 2020 Jan;3692(20):30022–32.
  10. Chandra H, Yadav JS. T-cell antigens of Mycobacterium immunogenum, an etiological agent of occupational hypersensitivity pneumonitis. Mol Immunol. 2016 Jul;75:168–77.
  11. De Sadeleer LJ, Hermans F, De Dycker E, Yserbyt J, Verschakelen JA, Verbeken EK, et al. Impact of BAL lymphocytosis and presence of honeycombing on corticosteroid treatment effect in Fibrotic Hypersensitivity Pneumonitis: a retrospective cohort study. Eur Respir J. 2020 Jan;1:1901983.
  12. Filev PD, Little BP, Duong P-AT. Second-Opinion Reads in Interstitial Lung Disease Imaging: Added Value of Subspecialty Interpretation. J Am Coll Radiol. 2020 Jan;1(19):1546.
  13. Kuranishi L, Storrer K. Chronic hypersensitivity pneumonitis. J Asthma Allergy. 2016;9:171–81.
  14. Walscher J, Gross B, Morisset J, Johannson KA, Vasakova M, Bruhwyler J, et al. Comorbidities and survival in patients with chronic hypersensitivity pneumonitis. Respir Res. 2020 Jan;21(1):12.

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