Pengaruh polisakarida dalam panax ginseng untuk vaksinasi flu burung (H5N1)

Geri Indra Herlambang(1Mail), Putu Ristyaning Ayu Sangging(2),
(1) Lampung University, Indonesia
(2) Lampung University, Indonesia

Mail Corresponding Author



Full Text:    Language : Ind

Abstract


Avian Influenza disease is caused by an avian influenza virus infection that became one of the biggest causes of death in the world. The subtype of the virus present in Indonesia is the H5N1 virus. According to the World Health Organization (WHO), in 2012, the outbreak of the H5N1 subtype avian influenza virus was first reported in 1996, Guangdong Province, South China, and spread to Indonesia since 2003. The number of death from avian influenza outbreak (H5N1) in Indonesia was recorded to be the highest in the world, with the number of death was 151 of 183 people who positively infected with the virus. The H5N1 virus can enter and infect humans when the body’s immune system of the person is low. Panax ginseng belongs to the Araliaceae family, which contains several components, such as ginsenosides, polyacetylenes, polyphenols, and polysaccharides. The Polysaccharides in Panax ginseng have an immunomodulatory function that can increase cytokine production and activate macrophages as an effort to improve and increase the body’s immune system. Therefore, polysaccharides in Panax ginseng affect avian influenza vaccination because it enhances the body’s immune response.


Keywords


Avian influenza; Panax ginseng; Polysaccharides; Vaccination

References


Alexander D. J. and I. H. Brow (2000). Recent zoonoses caused by influenza A viruses. Revue Scientifiqueet Technique. 1(19):197–225. Retrieve from: https://www.ncbi.nlm.nih.gov/pubmed/11189716

Auwalu Y, Sanpha K, Xingang Yu, Yongliang Z, Gnuqing L. (2016). Vaccination with Astragalus and Ginseng Polysaccharides Improves Immune Response of Chickens against H5N1 Avian Influenza Virus. Reasearch Articel. BioMed Reasearch International 1(1): 1-8. Retrieve from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002477/pdf/BMRI2016-1510264

Baek SH, Bae ON, Park JH. (2012). Recent methodology in ginseng analysis. J Ginseng Res.36:119-134. Retrieve from: http://koreascience.or.kr/article/JAKO201212851254119.page

Ernawati R, Putranto E, Hanief M. (2011). Kandidat vaksin flu burung H5N1 bagi ternak ayam isolat asal Jawa Timur. Jurnal Ilmiah Kedokteran Hewan, 1(4):19-24. Retrieve from: http://journal.unair.ac.id/downloadfull/VetMed5851-49ffea6c1efullabstract.pdf

Fauquet CM, Mayo MA, Maniloff J, Desselberger U dan Ball LA. (eds). (2005).Virus taxonomy: classification and nomenclature of viruses: eight report of the International Committee on the taxonomy of viruses. San diego: Elsevier Academic Press. Retrieve from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1208960/

Janovie A, Rusdi, Supiyani A. (2014). Uji efektivitas vaksin flu burung subtipe H5N1 pada ayam kampung di Legok, Tangerang, Banten. Jurnal BIOMA, 2(10):35-40. Retrieve from: http://journal.unj.ac.id/unj/index.php/bioma/article/view/462

Park EH, Yum J, Ku KB, Kim HM, Kang YM. (2013). Red ginseng-containing diet helps to protect mice and ferrets from the lethal infection by highly pathogenic H5N1 influenza virus. Journal Of Ginseng Research. 1(38):40-46. Retrieve from: https://www.ncbi.nlm.nih.gov/pubmed/24558309

Puspitaningrum I, Kusmita I, Franyoto Y. (2015). Aktivitas Imunomodulator Fraksi Etil Asetat Daun Som Jawa (Talinum triangulare (Jacq.) Willd) Terhadap Respon Imun Non Spesifik. Jurnal Media Neliti.1(1): 24-29. Retrieve from: https://www.neliti.com/publications/101337/aktivitas-imunomodulator-fraksi-etil-asetat-daun-som-jawa-talinum-triangulare-ja

Radji, Maksum. (2006). Avian influenza A (H5N1): Patogenesis, pencegahan dan penyebaran pada manusia. Jurnal Ilmu Kefarmasian.2(3): 55-65. Retrieve from: http://psr.ui.ac.id/index.php/journal/article/view/3399

Smith GJ, Naipospos TSP, Nguyen TD, De Jong MD, Vijaikrisnha D, Usman TB, Hassan SS, Nguyen TV, Dao TV, Bui NA, Leung YLC, Cheung CL, Rayner , Webster RG, Chen H, Peiris JSM, Yuan G. (2006). Evolution and adaptation of H5N1 influenza virus in avian and human host in Indonesia and Vietnam. Jurnal Virology, 350:258-268. Retrieve from: https://www.ncbi.nlm.nih.gov/pubmed/16713612

Soowon K, Hyeyoung M. (2012). Ginseng, the 'Immunity Boost': The effects of Panax ginseng on immune system. Journal Of Ginseng Research. 4(36):354-368. Retrieve from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659612/

Suarez D. L. and S. Schultz-Cherry. (2000). Immunology of avian influenza virus. Developmental and Comparative Immunology. 2(4):269–283. Retrieve from: https://www.ncbi.nlm.nih.gov/pubmed/10717293

Helm S. (2004). Cancer prevention and therapeutics: Panax ginseng.14(2):172-176. Retrieve from: https://www.ncbi.nlm.nih.gov/pubmed/15387718

World Health Organization. (2005). Evolution of H5N1 avian Influenza viruses in Asia. Emerg Infect Dis 11:15151521. Retrieve from: https://www.who.int/influenza/human_animal_interface/avian_influenza/h5n1-2011_08_30/en/

World Health Organization. (2012). H5N1 Avian influenza: Timeline of Major Events 11 Januari 2012. Retrieve from: https://www.who.int/influenza/human_animal_interface/H5N1_avian_influenza_update


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