Faktor-faktor penyebab terjadinya karsinoma nasofaring (KNF)
(1) Lampung University, Indonesia
Full Text: Language : ind
Nasopharyngeal carcinoma is a common disease in southern China. The etiologies of the main factors proposed for the pathogenesis of KNF include genetic factors, environmental factors and Epstein Barr Virus (EBV) infection. Other causes besides preserved food consumption include salted fish which have been involved in the etiology of NPC. The downward trend in the incidence of NPC has occurred in Hong Kong for the past 20 years, which is caused by changes in dietary habits. Despite the close relationship of EBV infection with NPC, the etiological role of EBV in the pathogenesis of NPC remains an interaction. EBV infection in primary nasopharyngeal epithelial cells occurs. Epstein Barr virus does not convert primary nasopharyngeal epithelial cells into proliferative clones, which is in sharp contrast to the well-documented ability of EBV to alter and perpetuate primary B cells. Genetic changes that are supported in the nasopharyngeal epithelium may be needed to support stable EBV infection. Non-viral factors as a cause of nasopharyngeal carcinoma still cannot be resolved with certainty. Non-viral factors are one of the risk factors that can increase the number of events arising from nasopharyngeal malignancies such as smoke, salted fish, formaldehyde, genetic, as soon as possible firewood, wood dust, chronic infection, throat protector, alcohol and traditional medicine.
Ali, M.Y. (1965). Histology of the human nasopharyngeal mucosa. J Anat 1965;99(3):657–72.
Buell, P. (1974) The effect of migration on the risk of nasopharyngeal cancer among Chinese. Cancer Res 1974;34(5):1189–91.
Chang, E.T, Adami, H.O. (2006) The enigmatic epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev 2006;15(10):1765–77.
Chien, Y.C., Chen, J.Y., Liu, M.Y., Yang, H.I., Hsu, M.M., Chen, C.J., et.al. (2001). Serologic markers of Epstein–Barr virus infection and nasopharyngeal carcinoma in Taiwanese men. N Engl J Med 2001;345(26):1877–82
Epstein, M.A., Achong, B.G., Barr, Y.M. (1964). Virus particles in cultured lymphoblasts from Burkitt’s Lymphoma. Lancet 1964;1(7335):702–3.
Henle, W., Henle, G., Ho, H.C., Burtin, P., Cachin, Y., Clifford, P., et.al. (1970). Antibodies to Epstein–Barr virus in nasopharyngeal carcinoma, other head and neck neoplasms, and control groups. J Natl Cancer Inst 1970;44(1):225–31.
Hildesheim, A., Apple, R.J., Chen, C.J., et.al. (2002). Association of HLA class I and II alleles and extended haplotypes with nasopharyngeal carcinoma in Taiwan. J Natl Cancer Inst 94(23):1780–1789
Hsu, W.L., Chen, J.Y., Chien, Y.C., Liu, M.Y., You, S.L., Hsu, M.M., et.al. (2009). Independent Effect of EBV and Cigarete Smoking on Nasopharyngeal Carcinoma : A 20 – Year Follow up Study on 9,662 Males without Family History in Taiwan. Cancer Epidemiol Biomarkers Prev 2009;18(4):1218-26
Jia, W.H., Feng, B.J., Xu, Z.L., et.al. (2004). Familial risk and clustering of nasopharyngeal carcinoma in Guangdong, China. Cancer 101(2):363–369
Levine, P.H., Pocinki, A.G., Madigan, P., et.al. (1992). Familial nasopharyngeal carcinoma in patients who are not Chinese. Cancer 70(5):1024–1029
Lo, A.K., Huang, D.P., Lo, K.W., et.al. (2004). Phenotypic alterations induced by the Hong Kong-prevalent Epstein–Barr virusencoded LMP1 variant (2117-LMP1) in nasopharyngeal epithelial cells. Int J Cancer 109(6):919–925
Lo, K.W., To, K.F., Huang, D.P. (2004) Focus on nasopharyngeal carcinoma. Cancer Cell 2004;5(5):423–8
Marks, J.E., Phillips, J.L., Menck, H.R. (1998). The National Cancer Data Base report on the relationship of race and national origin to the histology of nasopharyngeal carcinoma. Cancer 83(3):582–588
Rahman, S., Budiman, B.J., Subroto, H. (2015). Faktor Risiko Non Viral Pada Karsinoma Nasofaring. Jurnal Kesehatan Andalas; 4(3): hal 988-94
Rickinson, A.B., Kieff, E.D. (2007). Epstein–Barr virus. In: Knipe DM, Howley PM, editors. Fields virology. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2007. p. 2656–700
Sham, J.S., Wei, W.I., Zong, Y.S, et.al. (1990). Detection of subclinical nasopharyngeal carcinoma by fi breoptic endoscopy and multiple biopsy. Lancet 335(8686):371–374
Shanmugaratnam, K. (1978) Histological typing of nasopharyngeal carcinoma. IARC Sci Publ (20):3–12
Vasef, M.A., Ferlito, A., Weiss, L.M. (1997). Nasopharyngeal carcinoma, with emphasis on its relationship to Epstein–Barr virus. Ann Otol Rhinol Laryngol 106(4):348–356
Wei, M.X., de Turenne-Tessier, M., Decaussin, G., et.al. (1997). Establishment of a monkey kidney epithelial cell line with the BARF1 open reading frame from Epstein–Barr virus. Oncogene 14(25):3073–3081
Wu, Y.T., Luo, H.L., Johnson, D.R. (1986). Effect of nickel sulfate on cellular proliferation and Epstein–Barr virus antigen expression in lymphoblastoid cell lines. Cancer Lett 32(2):171–179
Yu, M.C., Yuan, J.M. (2002). Epidemiology of nasopharyngeal carcinoma. Semin Cancer Biol 12(6):421–429Zeng, Y.X., Jia, W.H. (2002). Familial nasopharyngeal carcinoma. Semin Cancer Biol 12(6):443–450
Article MetricsAbstract Views : 89 times
Fulltext Downloaded : 118 times
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.